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克魯勃SYNTHESO XOL 12 克魯勃SYNTHESO XOL 12 克魯勃SYNTHESO XOL 12 The GHS directive was brought into force by the European Commission in January 2009. Rules for substances and mixtures are to be implemented by December 2010 and June 2015, respectively. During a period of transition, the previous and new classification and labelling systems will exist side by side. All substances and mixtures are assigned hazard classes and hazard categories and labelled with new hazard symbols according to their grading.